Showing posts with label opioids. Show all posts
Showing posts with label opioids. Show all posts

Tuesday, April 11, 2017

Better than your current pain killer...


 

Cannabis extract (CBD) might be the opioid, ibuprofen or Aspirin replacement you’re looking for…

A groundbreaking study has documented the superior therapeutic properties of whole plant CBD-rich medicinal cannabis extract as compared to synthetic, single-molecule cannabidiol (CBD), Aspirin (non-steroid anti-inflammatory) or Tramadol (an opioid pain medication).
“Our data together with those of others provide legitimation to introduce a new generation of phytopharmaceuticals to treat diseases that have hitherto been treated using synthetic drugs alone,” the Israeli team reported.

This study leads the way for the use of whole plant CBD rich medicinal cannabis as a combined pain-management and anti-inflammatory treatment, and further confirms its superiority over single-molecule, synthetic CBD only treatments, and as a replacement for non-steroidal anti-inflammatory (for example the NSAIDs: Aspirin, Nurofen, Voltaren) and addictive opioid treatment regimes.

References: Ruth Gallily, Zhannah Yekhtin, Lumír Ondřej Hanuš, “Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol,” Pharmacology & Pharmacy (Feb. 2015), 



Supplements, who really needs them?


You’ve probably heard a lot in the press about the ineffectiveness of vitamin supplements. You’ve probably also heard about ground-breaking studies showing the benefit of plant-based extracts in the treatment of hard-to-manage conditions. Why do these reports seem to contradict each other?

Well not all supplements are equal, and their clinical use is difficult to patent and produce at standards acceptable to the various regulatory bodies that govern medicines around the world. While difficult, though, it is not impossible. Recently more research has begun into therapeutic botanical extracts and better ways to produce them, and the evidence is compelling.

Think of it like this: while eating an apple a day is beneficial to health, taking synthetic versions of the vitamins and minerals found in an apple might provide little or no benefit. That’s because there are dozens if not hundreds of other molecules bound up in that apple that help it to support human health, that aren’t in the supplement.

The rule of thumb is, if a supplement is made of a whole-plant extract, and you can find peer-reviewed studies to support it, then it’s probably going to help for the conditions indicated in the study. If, however it’s a synthetic copy or just contains a couple of the molecules found in the plant, then odds are it will just help you to make extremely expensive urine. The other alternative, of course, is to simply eat the apple.




Monday, March 13, 2017

Cannabis shows promise in treating meth and opioid addiction


The International Journal of Drug Policy recently concluded a major Canadian based study into the effect of medicinal cannabis on pain management, tobacco use and prescription drug addiction. 63% of the 271 study participants reported that they managed pain more effectively with cannabis and preferred it to prescriptions pain medications. 30% of participants preferred cannabis to using highly addictive opioids. 12% of recipients had used cannabis to quit their tobacco addiction (Lucas, 2017).

In another review, The National Institutes of Health concluded that a "growing number of studies support a critical role (in addiction pathways) and provide further evidence that the cannabinoid system could be explored as a potential drug discovery target for treating addiction across different classes of stimulants" (Oliere, 2013).

 Studies, such as this one, are overturning the false belief that cannabis is a gateway to more potent drug addictions, and instead shows that medicinal cannabis is an effective and safe pain management treatment, helping sufferers avoid developing dangerous addictions to opioids and other pain medications while adequately relieving pain.

In a separate study, The National Academy of Sciences, found that there is no valid evidence connecting marijuana with increased usage of other illicit substances. As a result the US Federal Drug Administration (FDA) was forced to remove unsubstantiated claims about marijuana being a gateway drug from its website.

This move is in line with a growing body of evidence substantiating the medicinal applications of cannabis for chronic pain and otherwise untreatable conditions. While smoking marijuana does not provide optimal dose or quality control, formulations based on Cannabinoid extracts and delivered as an oil, capsule, dermal patch or via metered inhaler show great promise with few if any side-effects.

As the peak medical practitioner body the AMA must now be under pressure to update its policy on medicinal cannabis and work with the TGA to support practitioner education and licensing, to meet the growing, medicinal demand.

Industry Expert: Elisabetta L. Faenza Co-founder – LeafCann

References

Lucas, Phillipe and Walsh, Zach, April 2017, Medicinal cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical cannabis patients,  The International Journal of Drug Policy, , Vol 42, pages 30 -35

National Academies of Sciences, Engineering and Medicine, 2017, The health effects of cannabis and cannabinoids: Current state of evidence and recommendations for research. Washignton, DC: The National Academies Press

Oliere, Staphanie, Jolette-Riopel, Antoine, Polvin, Stephane, Justras-Aswad, Didier, 2013 Modulation of the Endocannabinoid System; Vulnerability Factor and new Treatment Target for Stimulant Addiction, Semantic Scholar, Psychiatry, 2013
Cited at https://www.semanticscholar.org/paper/Modulation-of-the-Endocannabinoid-System-Oli%C3%A8re-Jolette-Riopel/34df4fecc92104d004b46665fa6963681627d928

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